• Source: Leukocyte immunoglobulin-like receptors

The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains.
They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells. The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13.4.
They include

LILRA1
LILRA2
LILRA3
LILRA4
LILRA5
LILRA6
LILRB1
LILRB2
LILRB3
LILRB4
LILRB5
LILRB6 or LILRA6
LILRB7 or LILRA5
A subset of LILR recognise MHC class I (also known as HLA class I in humans). The LILR family is a cluster of paired receptors with both activating and inhibitory functions. Of these, the inhibitory receptors LILRB1 and LILRB2 show a broad specificity for classical and non-classical MHC alleles with preferential binding to b2m-associated complexes. In contrast, the activating receptors LILRA1 and LILRA3 prefer b2m-independent free heavy chains of MHC class I, and in particular HLA-C alleles.




See also


LAIR1
Killer-cell immunoglobulin-like receptor




References

Kata Kunci Pencarian:

• Sel pembunuh alami
• Sistem imun
• Reseptor terhubung-protein G adhesi
• Leukocyte immunoglobulin-like receptors
• Immunoglobulin superfamily
• Killer-cell immunoglobulin-like receptor
• Leukocyte immunoglobulin-like receptor pseudogene 2
• List of gene families
• LRC
• Immunoglobulin A
• Fc receptor
• Cytokine receptor
• Toll-like receptor