- Source: Lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
Lipid IVA 4" target="_blank">4-amino-4" target="_blank">4-deoxy-L-arabinosyltransferase (EC 2.4" target="_blank">4.2.43, undecaprenyl phosphate-alpha-L-Ara4N transferase, 4" target="_blank">4-amino-4" target="_blank">4-deoxy-L-arabinose lipid A transferase, polymyxin resistance protein PmrK, arnT (gene)) is an enzyme with systematic name 4" target="_blank">4-amino-4" target="_blank">4-deoxy-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate:lipid IVA 4" target="_blank">4-amino-4" target="_blank">4-deoxy-L-arabinopyranosyltransferase. This enzyme catalyses the following chemical reaction
(1) 4" target="_blank">4-amino-4" target="_blank">4-deoxy-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate + alpha-Kdo-(2->4" target="_blank">4)-alpha-Kdo-(2->6)-lipid A
⇌
{\displaystyle \rightleftharpoons }
alpha-Kdo-(2->4" target="_blank">4)-alpha-Kdo-(2->6)-[4" target="_blank">4-P-L-Ara4N]-lipid A + ditrans, octacis-undecaprenyl phosphate
(2) 4" target="_blank">4-amino-4" target="_blank">4-deoxy-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate + lipid IVA
⇌
{\displaystyle \rightleftharpoons }
lipid IIA + ditrans, octacis-undecaprenyl phosphate
(3) 4" target="_blank">4-amino-4" target="_blank">4-deoxy-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate + alpha-Kdo-(2->4" target="_blank">4)-alpha-Kdo-(2->6)-lipid IVA
⇌
{\displaystyle \rightleftharpoons }
4" target="_blank">4'-alpha-L-Ara4N-alpha-Kdo-(2->4" target="_blank">4)-alpha-Kdo-(2->6)-lipid IVA + ditrans, octacis-undecaprenyl phosphate
This integral membrane protein is present in the inner membrane of certain Gram negative endobacteria.
References
External links
Lipid+IVA+4" target="_blank">4-amino-4" target="_blank">4-deoxy-L-arabinosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)