• Source: List of progestogens

This is a list of progestogens that are or that have been used in clinical or veterinary medicine. They are steroids and include derivatives of progesterone and testosterone.




Progesterone derivatives






= Retroprogesterone derivatives

=

Note that although an active progestogen, retroprogesterone is not medically used.




= 17α-Hydroxyprogesterone derivatives

=

Note that 17α-hydroxyprogesterone is inactive as a progestogen and is not used medically.
The 19-norprogesterone derivatives gestonorone caproate (gestronol hexanoate), nomegestrol acetate, segesterone acetate (nestorone, elcometrine), and norgestomet are also derivatives of 17α-hydroxyprogesterone (see below).




= 17α-Methylprogesterone derivatives

=

Note that although an active progestogen, 17α-methylprogesterone is not medically used.
The 19-norprogesterone derivatives demegestone, promegestone, and trimegestone are also derivatives of 17α-methylprogesterone (see below).




= Other 17α-substituted progesterone derivatives

=




= 19-Norprogesterone derivatives

=

Note that although an active progestogen, 19-norprogesterone is not medically used.




Testosterone derivatives



Note that testosterone itself does not have significant progestogenic activity. Testosterone is instead classified as an anabolic-androgenic steroid and is included here purely because it is the parent structure of this group of progestins.




= 17α-Ethynyltestosterone derivatives

=




= 19-Nortestosterone derivatives

=

Note that while nandrolone (19-nortestosterone) does have significant progestogenic activity, it is not used as a progestogen. It is instead classified as an androgenic-anabolic steroid and is included here purely because it is an important parent structure of this group of progestins.




= 17α-Ethynyl-19-nortestosterone derivatives

=



Estranes




18-Methylestranes (13β-ethylgonanes)





= Other 17α-substituted 19-nortestosterone derivatives

=




Spirolactone derivatives



Note that although an active progestogen, SC-5233 (spirolactone) is not medically used.




See also


List of steroids
List of progestogen esters




Notes


? = Chemical names that are unverified.




Further reading


McRobb L, Handelsman DJ, Kazlauskas R, Wilkinson S, McLeod MD, Heather AK (2008). "Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay". J. Steroid Biochem. Mol. Biol. 110 (1–2): 39–47. doi:10.1016/j.jsbmb.2007.10.008. PMID 18395441. S2CID 5612000.

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