- Source: Loganate O-methyltransferase
In enzymology, a loganate O-methyltransferase (EC 2.1.1.50) is an enzyme that catalyzes the chemical reaction.
S-adenosyl-L-methionine + loganic acid
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + loganin
Thus, the two substrates of this enzyme are S-adenosyl methionine and loganic acid (also called loganate), whereas its two products are S-adenosylhomocysteine and loganin.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon-group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:loganate 11-O-methyltransferase. Other names in common use include loganate methyltransferase and S-adenosyl-L-methionine:loganic acid methyltransferase. This enzyme participates in terpene indole and ipecac alkaloid biosynthesis.
References
Madyastha KM, Guarnaccia R, Baxter C, Coscia CJ (1973). "S-Adenosyl-L-methionine: loganic acid methyltransferase. A carboxyl-alkylating enzyme from Vinca rosea". J. Biol. Chem. 248 (7): 2497–501. PMID 4698228.
