• Source: LPAR1

Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene. LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).




Function


The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.




Cancer


LPAR1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.




Evolution






= Paralogues

=
Source:

LPAR2
LPAR3
S1PR1
S1PR3
S1PR5
S1PR4
S1PR2
CNR1
MC3R
MC5R
MC4R
GPR12
MC2R
GPR6
CNR2
GPR3
MC1R
GPR119




See also


Lysophospholipid receptor




References






Further reading






External links


"Lysophospholipid Receptors: LPA1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/2
• LPAR1
• C10orf35
• List of human protein-coding genes 2
• Cannabinoid receptor 1
• Melanocortin 1 receptor
• Lysophosphatidic acid receptor
• Cannabinoid receptor 2
• Lysophosphatidic acid
• Rhodopsin-like receptors
• FAM210B