• Source: Lymphangiogenesis

Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar to angiogenesis (blood vessel development).
Lymphangiogenesis plays an important physiological role in homeostasis, metabolism and immunity. Impaired or excessive lymphatic vessel formation has been implicated in a number of pathological conditions including neoplasm metastasis, oedema, rheumatoid arthritis, psoriasis, lymphangiomatosis and impaired wound healing.
The role of the lymphatic system in these diseases has received renewed interest largely due to the discovery of lymphatic endothelial cell (LEC)-specific markers such as podoplanin, LYVE-1, PROX1, desmoplakin and VEGF-C receptor VEGFR-3. These specific markers have enabled insights into functional and molecular lymphatic biology. There are several known pro-lymphangiogenesis inducers such as VEGF-C, hyaluronic acid and ephrin-B2.




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Further reading


Lymphangiogenesis and disease
Plate, Karl H (2001). "From angiogenesis to lymphangiogenesis". Nature Medicine. 7 (2): 151–152. doi:10.1038/84579. PMID 11175837. S2CID 27646199.
Jell, Gavin; Kerjaschki, Dontscho; Revell, Peter; Al-Saffar, Najat (2006). "Lymphangiogenesis in the bone–implant interface of orthopedic implants: Importance and consequence". Journal of Biomedical Materials Research Part A. 77A (1): 119–127. doi:10.1002/jbm.a.30548. PMID 16392126.
Ji, Rui-Cheng (2006). "Lymphatic Endothelial Cells, Lymphangiogenesis, and Extracellular Matrix". Lymphatic Research and Biology. 4 (2): 83–100. doi:10.1089/lrb.2006.4.83. PMID 16808670.

Kata Kunci Pencarian:

• Lymphangiogenesis
• Vascular endothelial growth factor
• MMP2
• Lymphatic system
• Hyaluronic acid
• Lymph sacs
• Sirolimus
• Lymphovascular invasion
• Hennekam syndrome
• Lec