- Source: MALAT1
MALAT 1 (metastasis associated lung adenocarcinoma transcript 1) also known as NEAT2 (noncoding nuclear-enriched abundant transcript 2) is a large, infrequently spliced non-coding RNA, which is highly conserved amongst mammals and highly expressed in the nucleus. It regulates the expression of metastasis-associated genes. It also positively regulates cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes. MALAT1 may play a role in temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta).
Expression in alcoholic brains
Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.
Prognostic potential in cancer
Elevated MALAT1 expression is correlated with poor overall survival in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer.
See also
Long non-coding RNA
MALAT1-associated small cytoplasmic RNA
References
Further reading
External links
OMIM page for MALAT1
HGNC page for MALAT1 Archived 2013-09-17 at the Wayback Machine
Page for Metastasis associated lung adenocarcinoma transcript 1 at Rfam
Relevance of MALAT1 in single-cell RNA sequencing data
Kata Kunci Pencarian:
- MALAT1
- MALAT1-associated small cytoplasmic RNA
- Gestational choriocarcinoma
- Triple helix
- Fluorescence in situ hybridization
- Renal cell carcinoma with t(6;11) translocation
- Gastroblastoma
- Long non-coding RNA
- Gapmer
- Epigenetics of human development
