- Source: MALAT1-associated small cytoplasmic RNA
MALAT1-associated small cytoplasmic RNA, also known as mascRNA, is a non-coding RNA found in the cytosol. This is a small RNA, roughly 53–61 nucleotides in length, that is processed from a much longer ncRNA called MALAT1 by an enzyme called RNase P. This RNA is expressed in many different human tissues, is highly conserved by evolution and shares a remarkable similarity to tRNA which is also produced by RNase P, yet this RNA is not aminoacylated in HeLa cells. The primary transcript, MALAT1 (metastasis associated lung adenocarcinoma transcript 1), appears to be upregulated in several malignant cancers.
Another small RNA that is homologous to mascRNA, called menRNA, is processed from another long ncRNA called MEN beta.
MALAT1 appears to be involved in the regulation of alternative splicing. MALAT1 interacts with SR proteins, influencing the distribution of these in nuclear speckle domains.
See also
Long noncoding RNA
MALAT1
NEAT1
References
Further reading
Bernard D, Prasanth KV, Tripathi V, Colasse S, Nakamura T, Xuan Z, Zhang MQ, Sedel F, Jourdren L, Coulpier F, Triller A, Spector DL, Bessis A (2010). "A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression". EMBO J. 29 (18): 3082–3093. doi:10.1038/emboj.2010.199. PMC 2944070. PMID 20729808.
Tano K, Mizuno R, Okada T, Rakwal R, Shibato J, Masuo Y, Ijiri K, Akimitsu N (2010). "MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes". FEBS Lett. 584 (22): 4575–4580. doi:10.1016/j.febslet.2010.10.008. PMID 20937273. S2CID 207575862.
External links
OMIM page for MALAT1
HGNC page for MALAT1
Page for MALAT1 at Rfam
Entrez Gene: MALAT1-associated small cytoplasmic RNA
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