- Source: Malate dehydrogenase (quinone)
In enzymology, a malate dehydrogenase (quinone) (EC 1.1.5.4), formerly malate dehydrogenase (acceptor) (EC 1.1.99.16), is an enzyme that catalyzes the chemical reaction
(S)-malate + a quinone
⇌
{\displaystyle \rightleftharpoons }
oxaloacetate + reduced quinone
Thus, the two substrates of this enzyme are (S)-malate and a quinone, whereas its two products are oxaloacetate and reduced quinone.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a quinone as acceptor. The systematic name of this enzyme class is (S)-malate:quinone oxidoreductase. Other names in common use include FAD-dependent malate-vitamin K reductase, malate-vitamin K reductase, and (S)-malate:(quinone) oxidoreductase. This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.
References
Imai D; Brodie AF (1973). "A phospholipid-requiring enzyme, malate-vitamin K reductase". J. Biol. Chem. 248 (21): 7487–7494. doi:10.1016/S0021-9258(19)43316-4.
Imai T (1978). "FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties". Biochim. Biophys. Acta. 523 (1): 37–46. doi:10.1016/0005-2744(78)90006-2. PMID 629992.
Prasada Reddy TL, Suryanarayana Murthy P, Venkitasubramanian TA (1975). "Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria". Biochim. Biophys. Acta. 376 (2): 210–8. doi:10.1016/0005-2728(75)90012-2. PMID 234747.
Kata Kunci Pencarian:
- Malate dehydrogenase (quinone)
- Malate dehydrogenase (disambiguation)
- Succinate dehydrogenase
- Malate–aspartate shuttle
- Malate dehydrogenase (NAD(P)+)
- Malate oxidase
- Citric acid cycle
- Respiratory complex I
- List of EC numbers (EC 1)
- Beta oxidation
