• Source: MAP3K11

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.




Function


The protein encoded by this gene is called MLK3 and it is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates JNK and p38, and is found to be involved in the transcription activity of AP1 mediated by Rho family GTPases and CDC42.




Interactions


MAP3K11 has been shown to interact with:

AKT1,
CDC42,
MAPK8IP1,
MAPK8IP2, and
SH3RF1.




References






Further reading

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/2
• MAP3K11
• MAP kinase kinase kinase
• Titin
• Protein kinase A
• Mitogen-activated protein kinase
• Mitogen-activated protein kinase kinase
• MAP kinase kinase kinase kinase
• C-Jun N-terminal kinases
• MTOR
• Phototropin