- Source: Mayesville Historic District
- Mayesville Historic District
- Mayesville, South Carolina
- Maysville Historic District
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- National Register of Historic Places listings in Sumter County, South Carolina
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- Sumter County, South Carolina
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Mayesville Historic District is a national historic district located at Mayesville, Sumter County, South Carolina. It encompasses 62 contributing buildings in the western half of the town of Mayesville. It includes a broad range of late-19th and early-20th century vernacular architectural design, including commercial, residential (majority), and religious buildings. The district includes representative examples of the Neo-Classical, Victorian, Queen Anne, Colonial Revival, Greek Revival, and Bungalow. Notable buildings include the Town Hall, Kineen Hotel, Bland Stables, Granit Building, Davis Store, J. W. Rhodes House, and R. J. Mayes House.
It was added to the National Register of Historic Places in 1979.