• Source: MBD3

Methyl-CpG-binding domain protein 3 is a protein that in humans is encoded by the MBD3 gene.




Function


DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA but instead binds to hydroxymethylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.
MBD3 also contains the coiled‐coil domain common to all three MBD3 isoforms.




Interactions


MBD3 has been shown to interact with:

AURKA,
GATAD2B,
HDAC1,
MTA2, and
MBD2.




References






Further reading

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/2
• MBD3
• Methyl-CpG-binding domain protein 2
• List of human protein-coding genes 2
• List of human transcription factors
• Jacob Hanna
• Induced pluripotent stem cell
• Methyl-CpG-binding domain
• MBD1
• GATAD2B
• Mi-2/NuRD complex