- Source: MBOAT5
Lysophospholipid acyltransferase 5 is an enzyme that in humans is encoded by the LPCAT3 gene.
It is homologous to other membrane-bound O-acyltransferases.
Structure and function
Based on the crystalographic and cryo-EM studies of its homolog in chicken (cLPCAT3), humane MBOAT5 has a typical MBOAT folding as other members such as SOAT1 and DGAT1, and the transmembrane helices hold a "T"-shape reaction chamber allowing the co-occupancy of a lysophosphatidylcholine (lysoPC) and a long polyunsaturated acyl-CoA, such as arachidonic acyl CoA. With the assistance of catalytic residues H374 and N338, the acyl chain could be transferred from the acyl CoA to the sn-2 position of lysoPC, thereby generating a new, polyunsaturated phospholipid.
Inhibition of LPCAT3 has been found to alter the cellular lipidome and is partially protective against ferroptosis.
References
Further reading
External links
LPCAT3 human gene location in the UCSC Genome Browser.
LPCAT3 human gene details in the UCSC Genome Browser.
