- Source: Melanin-concentrating hormone receptor
Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.
MCH-R1 is expressed in all mammals.
MCH-R2 is only found in some primates and carnivores including dogs, ferrets and humans.
Clinical significance
Antagonists might be useful in the treatment of obesity and anxiety and depression. An agonist might have possible utility as a treatment for osteoporosis and insomnia
Research is ongoing for antagonists affecting MCH receptors R1 and R2.
See also
Melanin concentrating hormone
Melanin
References
External links
"Melanin-Concentrating Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
melanin-concentrating+hormone+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
MCHR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
MCHR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)