• Source: Metanephrogenic blastema

The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud.
The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.
The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system. GDNF, glial cell-derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the RET receptor on the ureteric bud, which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts. Mutations in the EYA1 gene, whose product regulates GDNF expression in the developing kidney, lead to the renal abnormalities of BOR syndrome (branchio-oto-renal syndrome).




See also


Mesenchyme
Metanephros
Blastema
Kidney development




References






External links


Swiss embryology (from UL, UB, and UF) turinary/urinhaute01
genital-017a—Embryo Images at University of North Carolina
Diagram at mcgill.ca 1
Diagram at mcgill.ca 2
Qiao J, Cohen D, Herzlinger D (1995). "The metanephric blastema differentiates into collecting system and nephron epithelia in vitro". Development. 121 (10): 3207–14. doi:10.1242/dev.121.10.3207. PMID 7588055.

Kata Kunci Pencarian:

• Metanephrogenic blastema
• Development of the urinary system
• Nephron
• Mammalian kidney
• Loop of Henle
• Kidney development
• Distal convoluted tubule
• Intermediate mesoderm
• Mesoblastic nephroma
• Ureteric bud