- Source: Mexican Federal Highway 281
- Jaringan Nasional
- Dwight D. Eisenhower
- Mexican Federal Highway 281
- List of Mexican Federal Highways
- U.S. Route 281 in Texas
- List of highways numbered 1
- List of highways numbered 1000–1499
- List of highways numbered 281
- Mexican Federal Highway 293
- U.S. Route 281 in Kansas
- Mexican Federal Highway 261
- U.S. Route 550
Federal Highway 281 (Carretera Federal 281) is a Federal Highway of Mexico, located entirely within the state of Yucatán. It connects Celestún to Mérida, with a 23.2-kilometre (14.4 mi) spur from Hunucmá to Sisal. Within Mérida, the street is known as Avenida Jacinto Canek.