• Source: Michael Z. Lin

Michael Z. Lin (born 1973) is a Taiwanese-American biochemist and bioengineer. He is an associate professor of neurobiology and bioengineering at Stanford University. He is best known for his work on engineering optically and chemically controllable proteins.




Education and career


Lin graduated from Harvard University in 1994 with a degree in biochemical sciences summa cum laude. He subsequently trained as a PhD student studying neuronal signal transduction with Michael E. Greenberg at Harvard Medical School, graduating in 2002, and obtained a MD at UCLA in 2004. Lin then performed postdoctoral research with Chemistry Nobel Prize Laureate Roger Y. Tsien at UCSD. Since 2009, he has been a member of the faculty at the Stanford University School of Medicine.




Research


During postdoctoral training with Roger Y. Tsien, Lin developed improved red fluorescent proteins and channelrhodopsins, and pioneered the use of drug-regulated proteases for protein modification in the TimeSTAMP protein labelling method.
Lin's group at Stanford University has engineered proteins with novel functions for optogenetics, chemogenetics, and synthetic biology. Notable inventions include:

Red fluorescent and bioluminescent proteins
Optically switchable proteins using an engineered green fluorescent protein
The ASAP genetically encoded voltage indicator family
Chemical control of protein expression by proteases of RNA viruses
Synthetic proteins that rewire cancer signals to therapeutic activation
SARS-CoV-2 protease inhibitors based on modifying HCV protease inhibitors




Awards and honors


Burroughs Wellcome Fund Career Award in Medical Sciences (2007)
National Institutes of Health Director's Pioneer Award (2013)
Rita Allen Foundation Scholar (2016)
World Molecular Imaging Society Roger Tsien Awardee for Excellence in Chemical Biology (2019)




See also


Genetically encoded voltage indicator
Optogenetics
Chemogenetics
Chemical biology
Synthetic biology
Medicinal chemistry




References

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