- Source: Mir-744 microRNA precursor family
In molecular biology mir-744 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-744 and cancer in mice
miR-744 plays a role in tumour development and growth in mouse cell lines. Its expression induces cyclin B1 expression, whilst knockdown sees a resultant decreased level of mouse cyclin B through the Ccnb1 gene. Short-term overexpression of miR-744 in mouse cell lines has been seen to enhance cell proliferation, whilst chromosomal instability and in vivo suppression are concurrent with a prolonged expression.
TGF-β1 repression
Multiple miR-744 binding sites have been identified in the proximal 3' untranslated region of transforming growth factor beta 1 (TGF-β1). Direct targeting of TGF-β1 by miR-744 has been identified, and transfection is seen to inhibit endogenous TGF-β1 synthesis by directing post-transcriptional regulation.
EEF1A2 repression
miR-744 directly targets translation elongation factor and known protooncogene EEF1A2. mIR-744 also upregulates during resveratrol treatment of MCF7 breast cancer cells.
See also
MicroRNA
References
Further reading
Song, M. Y.; Pan, K. F.; Su, H. J.; Zhang, L.; Ma, J. L.; Li, J. Y.; Yuasa, Y.; Kang, D.; Kim, Y. S.; You, W. C. (2012). Califano, Joseph (ed.). "Identification of Serum MicroRNAs as Novel Non-Invasive Biomarkers for Early Detection of Gastric Cancer". PLOS ONE. 7 (3): e33608. Bibcode:2012PLoSO...733608S. doi:10.1371/journal.pone.0033608. PMC 3303856. PMID 22432036.
Mi, Q. S.; Weiland, M.; Qi, R. Q.; Gao, X. H.; Poisson, L. M.; Zhou, L. (2012). Homberg, Judith (ed.). "Identification of Mouse Serum miRNA Endogenous References by Global Gene Expression Profiles". PLOS ONE. 7 (2): e31278. Bibcode:2012PLoSO...731278M. doi:10.1371/journal.pone.0031278. PMC 3277497. PMID 22348064.
Chen, Y. Q.; Wang, X. X.; Yao, X. M.; Zhang, D. L.; Yang, X. F.; Tian, S. F.; Wang, N. S. (2012). "Abated microRNA-195 expression protected mesangial cells from apoptosis in early diabetic renal injury in mice". Journal of Nephrology. 25 (4): 566–576. doi:10.5301/jn.5000034. PMID 21983986.
Yoke-Kqueen, C.; Yoke-Kqueen, C.; Sabariah, A. R.; Shiran, M. S.; Singh, A.; Learn-Han, L. (2011). "Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers". International Journal of Molecular Medicine. 28 (3): 327–336. doi:10.3892/ijmm.2011.714. PMID 21637912.
External links
Page for mir-744 microRNA precursor family at Rfam