- Source: MYBL2
Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.
Function
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. MYBL2 is deregulated in various cancer types and can contribute to cancer progression.
Interactions
MYBL2 has been shown to interact with:
CDK9
CREB-binding protein
Cyclin A1
Cyclin-dependent kinase inhibitor 1C
EP300
PARP1
Retinoblastoma-like protein 1
References
Further reading
External links
MYBL2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.