• Source: N-Methyltryptamine

N-Methyltryptamine (NMT), also known as monomethyltryptamine, is a chemical compound of the tryptamine family and a naturally occurring compound found in the human body and certain plants.
It is biosynthesized in humans from tryptamine by certain N-methyltransferase enzymes, such as indolethylamine N-methyltransferase. It is a known component in human urine. NMT is an alkaloid derived from L-tryptophan that has been found in the bark, shoots and leaves of several plant genera, including Virola, Acacia, Mimosa, and Desmanthus—often together with the related compounds N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT).
NMT acts as a serotonin receptor agonist and serotonin releasing agent and produces psychoactive and hallucinogenic effects in humans.




Effects


Orally administered NMT appears to produce no psychoactive effects, likely as a result of extensive first-pass metabolism. However, it may become active upon combination with a MAOA inhibitor (MAOI).
By vaporization, NMT shows psychoactive activity at 50 to 100 mg, with a duration of 45 to 70 minutes; duration of visual effects is said to be only 15 to 30 seconds. Effects are primarily non-visual.




Pharmacology


NMT is known to act as a potent serotonin 5-HT2A receptor full agonist (EC50Tooltip half-maximal effective concentration = 50.7 nM; EmaxTooltip maximal efficacy = 96%). It has been reported to be inactive in activating the β-arrestin pathway of the receptor and hence appears to be a biased agonist of the serotonin 5-HT2A receptor. In contrast to the serotonin 5-HT2A receptor, the drug is not an agonist of the serotonin 5-HT1A receptor.
In addition to its serotonin 5-HT2A receptor agonism, NMT is a potent serotonin releasing agent (EC50 = 22.4 nM). It also releases dopamine and norepinephrine much more weakly (EC50 = 321 nM and 733 nM, respectively; 14- and 33-fold less than for serotonin, respectively).




Legality


In the United States NMT is considered a schedule 1 controlled substance as an positional isomer of Alpha-methyltryptamine (AMT)




See also


N-Ethyltryptamine (NET)
N,N,-Dimethyltryptamine (DMT)
Acacia confusa (a natural source of NMT, with other tryptamines, 1.63%. Buchanan et al. 2007)
Acacia obtusifolia (NMT up to 2/3 alkaloid content)
Acacia simplicifolia (synon. A. simplex) (1.44% NMT in bark, 0.29% twigs, Pouet et al. 1976)
Desmanthus illinoensis (NMT major component seasonally)




References






External links


NMT Entry in TIHKAL
NMT Entry in TiHKAL • info

Kata Kunci Pencarian:

• Panaeolus cinctulus
• Penggunaan zat adiktif
• N-Methyltryptamine
• Methyltryptamine
• N,N-Dimethyltryptamine
• 5,6-Dibromo-N-methyltryptamine
• N-Ethyltryptamine
• Substituted tryptamine
• BK-NM-AMT
• 2-HO-NMT
• Serotonin
• Baeocystin