• Source: Nicola Allen

Nicola J. Allen is a British neuroscientist. Allen studies the role of astrocytes in brain development, homeostasis, and aging. Her work uncovered the critical roles these cells play in brain plasticity and disease. Allen is currently an associate professor at the Salk Institute for Biological Studies and Hearst Foundation Development Chair.




Education


Allen conducted her undergraduate studies in Anatomical Sciences at the University of Manchester in England. She completed her doctoral degree in Neuroscience at University College London in the United Kingdom in the lab of David Attwell. She was a postdoctoral researcher in the lab of Ben Barres at Stanford University.




Research


Allen's research focuses on how astrocytes regulate synapses in the brain during disorders such as Alzheimer's disease. In 2012 while she was a postdoc in the lab of Ben Barres, she showed that astrocytes secrete glypican 4 and 6, which is needed to create glutamatergic synapses between neurons. She later expanded the research on glypican 4, showing that it is needed for the postsynaptic neurons to receive inputs. Allen also showed that astrocytes excrete a protein called Chrdl1, which helps the maturation of the brain. It also increased neuroplasticity in the brains of mice.
Allen uses ribo-tagging, which is a molecular technique to determine which proteins are made by the ribosomes. This technique allowed her to show that astrocytes make a protein that encourages the breakdown of connections between neurons.




Awards and honours


Ben Barres Early Career Acceleration Award from the Chan Zuckerberg Initiative (CZI) - 2018
Pew Scholar - 2015
Human Frontier Science Program (HFSP) Long Term Fellowship - 2005–2008
European Molecular Biology Organisation (EMBO) Long Term Fellowship - 2004–2005
Wellcome Trust PhD Fellowship - 1999–2003




Selected publications


Allen, Nicola J.; Eroglu, Cagla (2017). "Cell Biology of Astrocyte-Synapse Interactions". Neuron. 96 (3): 697–708. doi:10.1016/j.neuron.2017.09.056. ISSN 0896-6273. PMC 5687890. PMID 29096081.
Allen, Nicola J.; Bennett, Mariko L.; Foo, Lynette C.; Wang, Gordon X.; Chakraborty, Chandrani; Smith, Stephen J.; Barres, Ben A. (2012). "Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors". Nature. 486 (7403): 410–414. Bibcode:2012Natur.486..410A. doi:10.1038/nature11059. ISSN 1476-4687. PMC 3383085. PMID 22722203.
Allen, Nicola J.; Attwell, David (2002). "Modulation of ASIC channels in rat cerebellar purkinje neurons by ischaemia-related signals". The Journal of Physiology. 543 (2): 521–529. doi:10.1113/jphysiol.2002.020297. ISSN 1469-7793. PMC 2290513. PMID 12205186.




References

Kata Kunci Pencarian:

• Globalisasi
• WhatsApp
• Perjanjian Waitangi
• Jack Brown Genius
• Meta Platforms
• Protestanisme
• The Boys (seri televisi 2019)
• Smiley (film 2012)
• William, Pangeran Wales
• Piala Dunia U-17 FIFA 2023
• Nicola Allen
• Nicola Roberts
• Woody Allen
• Bambi: The Reckoning
• Nicola Green
• Visitation (film)
• Nicola Fox
• Semantic Scholar
• Lily Allen
• Allen Carr