• Source: Nicotinate phosphoribosyltransferase

In enzymology, a nicotinate phosphoribosyltransferase (EC 6.3.4.21) is an enzyme that catalyzes the chemical reaction

nicotinate + 5-phospho-α-D-ribose 1-diphosphate + ATP + H2O



⇌


{\displaystyle \rightleftharpoons }

nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
Thus, the four substrates of this enzyme are nicotinate, 5-phospho-alpha-D-ribose 1-diphosphate, ATP, and H2O, whereas its four products are nicotinate D-ribonucleotide, diphosphate, ADP, and phosphate.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming) .




Structural studies


As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1VLP, 1YBE, 1YIR, 1YTD, 1YTE, 1YTK, and 2F7F.




References



IMSANDE J (1961). "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli". J. Biol. Chem. 236 (5): 1494–7. doi:10.1016/S0021-9258(18)64203-6. PMID 13717628.
IMSANDE J, HANDLER P (1961). "Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase". J. Biol. Chem. 236 (2): 525–30. doi:10.1016/S0021-9258(18)64397-2. PMID 13717627.
Kosaka A, Spivey HO, Gholson RK (1971). "Nicotinate phosphoribosyltransferase of yeast. Purification and properties". J. Biol. Chem. 246 (10): 3277–83. doi:10.1016/S0021-9258(18)62224-0. PMID 4324895.

Kata Kunci Pencarian:

• Nicotinate phosphoribosyltransferase
• Nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase
• Nucleotide salvage
• Nicotinamide phosphoribosyltransferase
• Phosphoribosyl pyrophosphate
• Nicotinate-nucleotide diphosphorylase (carboxylating)
• Nicotinamide adenine dinucleotide
• List of EC numbers (EC 6)
• Neobacillus
• Mycobacteroides