- Source: Norfenefrine
Norfenefrine, also known as meta-octopamine or norphenylephrine and sold under the brand name Novadral among others, is a sympathomimetic medication which is used in the treatment of hypotension (low blood pressure). Along with its structural isomer p-octopamine and the tyramines, norfenefrine is a naturally occurring endogenous trace amine and plays a role as a minor neurotransmitter in the brain.
Medical uses
Norfenefrine is used in the treatment of hypotension (low blood pressure). It is said to be similarly effective or less effective than midodrine.
Pharmacology
= Pharmacodynamics
=Norfenefrine is described as an α-adrenergic receptor agonist and sympathomimetic agent. It is said to act predominantly as an α1-adrenergic receptor agonist.
Chemistry
Norfenefrine, also known as 3,β-dihydroxyphenethylamine, is a substituted phenethylamine derivative. It is an analogue of norepinephrine (3,4,β-trihydroxyphenethylamine), of meta-tyramine (3-hydroxyphenethylamine), of phenylephrine ((R)-β,3-dihydroxy-N-methylphenethylamine), of etilefrine (3,β-dihydroxy-N-ethylphenethylamine), and of metaterol (3,β-dihydroxy-N-isopropylphenethylamine), as well as of metaraminol ((1R,2S)-3,β-dihydroxy-α-methylphenethylamine).
Norfenefrine is used medically as the hydrochloride salt.
The predicted log P of norfenefrine is -0.28 to -0.95.
Society and culture
= Names
=Norfenefrine is the generic name of the drug and its INNTooltip International Nonproprietary Name. Synonyms of norfenefrine include hydroxyphenylethanolamine, nor-phenylephrine, and m-norsynephrine, among others. Brand names of norfenefrine include Novadral, A.S. COR, Coritat, Energona, Hypolind, Norfenefrin Ziethen, and Norfenefrin-Ratiopharm, among others.
= Availability
=Norfenefrine is marketed in Europe, Japan, and Mexico.
References
Kata Kunci Pencarian:
- Norfenefrine
- C8H11NO2
- List of drugs: Nj–Nz
- Cocaine
- Alpha-adrenergic agonist
- MDMA
- Caffeine
- Methamphetamine
- Methylphenidate
- Crack cocaine
