• Source: Nuclear receptor co-repressor 2

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression. NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT) or T3 receptor-associating cofactor 1 (TRAC-1).




Function


NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains. NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.




Family


It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.




Discovery


SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies. In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.




Interactions


Nuclear receptor co-repressor 2 has been shown to interact with:




References






Further reading






External links


nuclear receptor corepressor 2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
NURSA C98

Kata Kunci Pencarian:

• NF-κB
• Nuclear receptor co-repressor 2
• Nuclear receptor co-repressor 1
• Nuclear receptor
• Nuclear receptor 4A1
• Progesterone receptor
• Hormone receptor
• Transcription coregulator
• NCOR (disambiguation)
• SPEN
• Androgen receptor