- Source: O-Pivalylbufotenine
O-Pivalylbufotenine, or bufotenine O-pivalate, also known as 5-pivaloxy-N,N-dimethyltryptamine or O-pivalyl-N,N-dimethylserotonin, is a synthetic tryptamine derivative and putative serotonergic psychedelic. It is the O-pivalyl analogue of the naturally occurring but peripherally selective serotonergic tryptamine bufotenine (5-hydroxy-N,N-dimethyltrypamine or N,N-dimethylserotonin) and is thought to act as a centrally penetrant prodrug of bufotenine.
O-Pivalylbufotenine shows psychedelic-like effects in animals but is less active than anticipated, perhaps due to its high lipophilicity and, by extension, high plasma protein binding and ester hydrolysis into bufotenine prior to crossing the blood–brain barrier. In addition to theoretically acting as a prodrug of bufotenine, which is a non-selective serotonin receptor agonist, O-pivalylbufotenine may also interact directly with certain serotonin receptors.
Besides O-pivalylbufotenine, other bufotenine O-acyl esters and putative or confirmed bufotenine prodrugs, such as O-acetylbufotenine among others, have been developed and studied.
O-Pivalylbufotenine was first described in the scientific literature by 1979.
See also
4-AcO-DMT
O,O′-Diacetyldopamine
O,O′-Dipivaloyldopamine
α-Methyltryptophan
Neurotransmitter prodrug
