- Source: O6-Benzylguanine
O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair. O6-BG was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was found to be overly toxic without adding significant benefit.
O6-BG is also used as a biochemical tool in the study of DNA repair mechanisms.
References
External links
Friedman, HS (2000). "Can O6-alkylguanine-DNA alkyltransferase depletion enhance alkylator activity in the clinic?" (PDF). Clinical Cancer Research. 6 (8): 2967–8. PMID 10955771.