OPR may refer to:
Office of Planning and Research, an agency of the California government
Office of Population Research, the oldest population research center in the United States
Office of Professional Responsibility, part of the United States Department of Justice
Office of Professional Responsibility (IRS), part of the United States Internal Revenue Service responsible for investigating suspected practitioner misconduct
Office of Public Roads, a predecessor of the United States Federal Highway Administration
Official Pattern Release, used by Trend Micro to refer to the definitions for their antivirus products
Oregon Pacific Railroad (1880–94), in Oregon, United States
Oregon Pacific Railroad (1997), in Oregon, United States
Old Parochial Registers of the Church of Scotland
Output Recordings, a British independent record label run by Trevor Jackson, between 1996–2006
Outward Processing Relief, a 1989 U.K. statutory instrument
Overall pressure ratio, the ratio of the stagnation pressure as measured at the front and rear of the compressor of a gas turbine engine
Overland Park Regional Medical Center, a hospital in Overland Park, Kansas
Overnight Policy Rate, an overnight interest rate set by Bank Negara Malaysia used for monetary policy direction
Owner's project requirements, a foundational document for the design and commissioning of buildings; see New-construction building commissioning
Rodrigues People's Organisation (Organisation du Peuple Rodriguais), a Mauritian political party
P. Ravindhranath, an Indian politician known as OPR, the son of O. Panneerselvam (OPS)
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