• Source: Outline of life extension

The following outline is provided as an overview of and topical guide to life extension:
Life extension – study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. Also known as anti-aging medicine, experimental gerontology, and biomedical gerontology.




Goals


Biological immortality
Indefinite lifespan
Longevity
Rejuvenation




Longevity


Centenarian
Supercentenarian
Longevity escape velocity




Strategies






= Research and development

=
Timeline of senescence research




= Available strategies

=
Calorie restriction or protein restriction or intermittent fasting
Exercise
Geroprotector
Senolytics




= Potential future strategies

=
Cryonics
Genetic therapies
Cloning and body part replacement
Cell replacement therapies (CRT)
Strategies for engineered negligible senescence (SENS)
Digital immortality through mind uploading
Suspended animation
Immunisation




Aging


Evolution of ageing
Gerontology
Pro-aging trance




= Hallmarks of aging

=
Altered intercellular communication
Cellular senescence
Deregulated nutrient sensing
Epigenetic alterations
Genomic instability
Loss of proteostasis
Mitochondrial dysfunction
Stem cell exhaustion
Telomere attrition




= Causes of aging

=
Cross-links
Crosslinking of DNA
Free radicals – atom, molecule, or ion that has unpaired valence electrons. With some exceptions, these unpaired electrons make free radicals highly chemically reactive towards other substances, or even towards themselves: their molecules will often spontaneously dimerize or polymerize if they come in contact with each other. They are countered to some extent by antioxidants.
Glycation
Advanced glycation end-product
Lipofuscin
Viral infections (acute or chronic)



Theories of aging

Theories of aging

Antagonistic pleiotropy theory of aging
Caloric restriction theory
Cross-linkage theory of aging
Death hormone theory
Disposable soma theory of aging
DNA damage theory of aging
Epigenetic clock theory of aging
Error catastrophe theory of aging
Errors and Repairs Theory
Free-radical theory of aging
Gene mutation theory
Genetic control theory
Glycation theory of aging
Hayflick limit theory
Inflammation theory of aging
Immunological theory of aging
Log-normal theory of mortality
Membrane theory of aging
Mitochondrial Free Radical Theory of Aging
Mitochondrial Theory of Aging
Mutation accumulation theory of aging
Neuroendocrine theory of aging
Order to disorder theory of aging
Rate of living theory
Redundant DNA theory
Reliability theory of aging and longevity
Reproductive-cell cycle theory
Somatic mutation theory of aging
Telomeric theory of aging
Theory of programmed death
Thermodynamic theory of aging
Thymic-stimulating theory
Waste accumulation theory




Organizations


Alcor Life Extension Foundation
Altos Labs
Alliance for Aging Research
American Academy of Anti-Aging Medicine
American Aging Association
BioViva
Buck Institute for Research on Aging
Calico
Cryonics Institute
International Longevity Alliance
LEV Foundation
Life Extension Advocacy Foundation
Life Extension Foundation
Methuselah Foundation – non-profit organization dedicated to extending the healthy human lifespan by advancing tissue engineering and regenerative medicine therapies. It was co-founded in 2003 by Aubrey de Grey and David Gobel, and is based in Springfield, Virginia, United States.
SENS Research Foundation – 501(c)(3) non-profit organization co-founded by Michael Kope, Aubrey de Grey, Jeff Hall, Sarah Marr and Kevin Perrott, which is based in Mountain View, California, United States. Its activities include research programs and public relations work for the application of regenerative medicine to aging.




Notable people


Aubrey de Grey
Leonard Hayflick
Zoltan Istvan
Saul Kent
Cynthia Kenyon
Durk Pearson
Sandy Shaw
David Andrew Sinclair
Roy Walford
Michael D. West




See also


Attempts to engineer biological immortality in humans
Timeline of senescence research
Outline of transhumanism
Degeneration (medical)
Degenerative disease
Neurodegeneration




References






Further reading


Ending Aging, a 2007 book which describes Aubrey de Grey's medical proposal for defeating aging (i.e. SENS).




External links


SENS Research Foundation

Kata Kunci Pencarian:

• Outline of life extension
• Life extension
• Life extension (disambiguation)
• Altos Labs
• Anti-aging movement
• Biomedical Research & Longevity Society
• Rejuvenation
• Index of topics related to life extension
• Calico (company)
• Immortalist Society