• Source: Paritaprevir

Paritaprevir (previously known as ABT-450) is an acylsulfonamide inhibitor of the NS3-4A serine protease manufactured by Abbott Laboratories that shows promising results as a treatment of hepatitis C. When given in combination with ritonavir and ribavirin for 12 weeks, the rate of sustained virologic response at 24 weeks after treatment has been estimated to be 95% for those with hepatitis C virus genotype 1. Resistance to treatment with paritaprevir is uncommon, because it targets the binding site, but has been seen to arise due to mutations at positions 155 and 168 in NS3.: 248 
Paritaprevir was a component of Viekira Pak and Technivie. In May 2018, the FDA announced that Technivie and Viekira were to be discontinued. The discontinuation was voluntary and not related to the safety, quality, or efficacy of the medicine. It was estimated that both medications would be available until January 1, 2019.




References

Kata Kunci Pencarian:

• Sulfonamida (obat)
• Daftar Obat Esensial Organisasi Kesehatan Dunia
• Ritonavir
• Paritaprevir
• Ombitasvir/paritaprevir/ritonavir
• List of sulfonamides
• ATC code J05
• Dasabuvir
• Protease inhibitor (pharmacology)
• Hydrocodone
• Ombitasvir
• Ritonavir
• Hepatitis C