• Source: Phospholipid-hydroperoxide glutathione peroxidase

In enzymology, a phospholipid-hydroperoxide glutathione peroxidase (EC 1.11.1.12) is an enzyme that catalyzes the chemical reaction

2 glutathione + a lipid hydroperoxide



⇌


{\displaystyle \rightleftharpoons }

glutathione disulfide + lipid + 2 H2O
Thus, the two substrates of this enzyme are glutathione and lipid hydroperoxide, whereas its 3 products are glutathione disulfide, lipid, and H2O.
This enzyme belongs to the family of oxidoreductases, to be specific those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is glutathione:lipid-hydroperoxide oxidoreductase. Other names in common use include peroxidation-inhibiting protein, PHGPX, peroxidation-inhibiting protein: peroxidase, glutathione, (phospholipid hydroperoxide-reducing), phospholipid hydroperoxide glutathione peroxidase, hydroperoxide glutathione peroxidase, or glutathione peroxidase 4 (GPX4). This enzyme participates in glutathione metabolism.




Structural studies


As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2GS3 and 2OBI.




References



Ursini F, Maiorino M, Gregolin C (1985). "The selenoenzyme phospholipid hydroperoxide glutathione peroxidase". Biochim. Biophys. Acta. 839 (1): 62–70. doi:10.1016/0304-4165(85)90182-5. PMID 3978121.

Kata Kunci Pencarian:

• Phospholipid-hydroperoxide glutathione peroxidase
• Glutathione peroxidase 4
• Glutathione peroxidase
• Glutathione peroxidase 7
• Lipid peroxidation
• Ebselen
• Hepoxilin
• SEPP1
• List of EC numbers (EC 1)
• PRDX6