- Source: Phosphomethylpyrimidine synthase
Phosphomethylpyrimidine synthase (EC 4.1.99.17, thiC (gene)) is an enzyme with systematic name 5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming). This enzyme catalyses the following chemical reaction
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine
⇌
{\displaystyle \rightleftharpoons }
4-amino-2-methyl-5-phosphomethylpyrimidine + 5′-deoxyadenosine + L-methionine + formate + CO
This enzyme binds a 4Fe-4S cluster.
The starting material is 5-aminoimidazole ribotide, which undergoes a rearrangement reaction via radical intermediates which incorporate the blue, green and red fragments shown into the product.
References
External links
Phosphomethylpyrimidine+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
External links
Media related to Phosphomethylpyrimidine synthase at Wikimedia Commons
Kata Kunci Pencarian:
- Phosphomethylpyrimidine synthase
- Thiamine
- 4-Amino-5-hydroxymethyl-2-methylpyrimidine
- List of EC numbers (EC 4)
- 5-Aminoimidazole ribotide
- List of EC numbers (EC 2)
