• Source: PLS3

Plastin-3 is a highly conserved protein that in humans is encoded by the PLS3 gene on the X chromosome.




Function


Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N-terminus.




Clinical significance


Defects in PLS3 are associated with osteoporosis and bone fracture in humans and in knockout zebrafish.




References






Further reading

Kata Kunci Pencarian:

• PLS3
• PLSCR3
• Plastin
• List of human protein-coding genes 3
• EF hand
• Calponin homology domain
• Albert Hofman (epidemiologist)