• Source: Prephenate dehydratase

The enzyme prephenate dehydratase (EC 4.2.1.51) catalyzes the chemical reaction

prephenate



⇌


{\displaystyle \rightleftharpoons }

phenylpyruvate + H2O + CO2
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming). This enzyme is also called prephenate hydro-lyase (decarboxylating). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.




Structural studies


As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QMX.




References



CERUTTI P, GUROFF G (1965). "Enzymatic Formation of Phenylpyruvic Acid in Pseudomonas Sp. (Atcc 11299A) and ITS Regulation". J. Biol. Chem. 240 (7): 3034–8. doi:10.1016/S0021-9258(18)97282-0. PMID 14342329.
COTTON RG, GIBSON F (1965). "The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase". Biochim. Biophys. Acta. 100: 76–88. doi:10.1016/0304-4165(65)90429-0. PMID 14323651.
Schmidt JC; Zalkin H (1969). "Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium". Biochemistry. 8 (1): 174–181. doi:10.1021/bi00829a025. PMID 4887851.

Kata Kunci Pencarian:

• Prephenate dehydratase
• Arogenate dehydratase
• Prephenic acid
• Arogenic acid
• Shikimate pathway
• List of EC numbers (EC 4)
• List of MeSH codes (D08)
• Amino acid synthesis