- Source: Procollagen glucosyltransferase
In enzymology, a procollagen glucosyltransferase (EC 2.4.1.66) is an enzyme that catalyzes the chemical reaction
UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen
⇌
{\displaystyle \rightleftharpoons }
UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
Thus, the two substrates of this enzyme are UDP-glucose and 5-(D-galactosyloxy)-L-lysine-procollagen, whereas its two products are UDP and 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase. Other names in common use include galactosylhydroxylysine glucosyltransferase, collagen glucosyltransferase, collagen hydroxylysyl glucosyltransferase, galactosylhydroxylysyl glucosyltransferase, UDP-glucose-collagenglucosyltransferase, and uridine diphosphoglucose-collagen glucosyltransferase.
References
Bosmann HB, Eylar EH (1968). "Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase". Biochem. Biophys. Res. Commun. 30 (1): 89–94. doi:10.1016/0006-291X(68)90717-1. PMID 5637038.
Bosmann HB, Eylar EH (1968). "Collagen-glucosyl transferase in fibriblasts transformed by oncogenic viruses". Nature. 218 (5141): 582–3. doi:10.1038/218582a0. PMID 4968368.
Butler WT, Cunningham LW (1966). "Evidence for the linkage of a disaccharide to hydroxylysine in tropocollagen". J. Biol. Chem. 241 (17): 3882–8. doi:10.1016/S0021-9258(18)99789-9. PMID 4288358.
Kivirikko KI; Myllyla R (1979). Hall, D.A.; Jackson, D.S. (eds.). "Collagen Glycosyltransferases". International Review of Connective Tissue Research. 8. New York: Academic Press: 23. doi:10.1016/B978-0-12-363708-6.50008-4. ISBN 9780123637086. PMID 389860.
