- Source: Prostaglandin-A1 Delta-isomerase
In enzymology, a Prostaglandin-A1 Δ-isomerase (EC 5.3.3.9) is an enzyme that catalyzes the chemical reaction
(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate
⇌
{\displaystyle \rightleftharpoons }
(13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate
Hence, this enzyme has one substrate, (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate (Prostaglandin A1 or PGA1), and one product, (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate (Prostaglandin C1).
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate Delta10-Delta11-isomerase. This enzyme is also called prostaglandin A isomerase.
References
Polet H, Levine L (1975). "Metabolism of prostaglandins E, A, and C in serum". J. Biol. Chem. 250 (2): 351–7. PMID 234423.