- Source: Protein N-terminal methyltransferase
- Protein N-terminal methyltransferase
- Methyltransferase
- DNA methyltransferase
- Protein methylation
- Histone methyltransferase
- Protein-glutamate O-methyltransferase
- Protein arginine methyltransferase 5
- Glycylpeptide N-tetradecanoyltransferase 1
- C-terminus
- (Phosphatase 2A protein)-leucine-carboxy methyltransferase
Protein N-terminal methyltransferase (EC 2.1.1.244, NMT1 (gene), METTL11A (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase. This enzyme catalyses the following chemical reaction
(1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein]
⇌
{\displaystyle \rightleftharpoons }
3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] (overall reaction)
(1a) S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein]
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,S)PK-[protein]
(1b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-(A,S)PK-[protein]
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-(A,S)PK-[protein]
(1c) S-adenosyl-L-methionine + N-terminal-N,N-dimethyl-N-(A,S)PK-serine-[protein]
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
(2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein]
⇌
{\displaystyle \rightleftharpoons }
2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] (overall reaction)
(2a) S-adenosyl-L-methionine + N-terminal-PPK-[protein]
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-PPK-[protein]
(2b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-PPK-[protein]
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]
This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys.
References
External links
Protein+N-terminal+methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)