• Source: Pyrrolobenzodiazepine

Pyrrolobenzodiazepines, (PBD) are a class of compound that may have antibiotic or anti-tumor properties.
Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads in antibody-drug conjugates, for example in loncastuximab tesirine.




History


Anthramycin, the first PBD monomer, was first synthesized in the 1960s.




References

Kata Kunci Pencarian:

• Pyrrolobenzodiazepine
• KIT (gene)
• Vadastuximab talirine
• PBD
• Camidanlumab tesirine
• Tomaymycin
• Loncastuximab tesirine
• Tilivalline
• Anthramycin
• Sibiromycin