• Source: Quinazolinone

Quinazolinone is a heterocyclic chemical compound, a quinazoline with a carbonyl group in the C4N2 ring. Two isomers are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest in medicinal chemistry.













Synthesis


Common routes to quinazolines involve condensation of amides to anilines with ortho nitrile, carboxylic acids and amides.
Quinazolinone drugs that function as hypnotic/sedatives, methaqualone (Quaalude) for example, usually contain a 4-quinazolinone core with a 2-substituted phenyl group at nitrogen atom 3.




See also


Idelalisib (Zydelig)
Cloroqualone
SL-164 (Dicloqualone)
Diproqualone
Etaqualone
Mebroqualone
Mecloqualone
Methylmethaqualone
Nitromethaqualone




References

Kata Kunci Pencarian:

• Psikotropika
• Quinazolinone
• Depressant
• Methaqualone
• SL-164
• Hypnotic
• Afloqualone
• Ketamine
• MDMA
• Methamphetamine
• Cannabis (drug)