• Source: Quipazine

Quipazine is a serotonergic drug of the piperazine group which is used in scientific research. It was originally intended as an antidepressant but never developed for medical use.




Pharmacology






= Pharmacodynamics

=
Quipazine is a serotonin reuptake inhibitor, and also a moderately selective serotonin receptor agonist, binding to a range of different serotonin receptors, but particularly to the 5-HT2A and 5-HT3 subtypes. Activation of the serotonin 5-HT3 is implicated in inducing nausea and vomiting.
Quipazine produces a head-twitch response and other psychedelic-consistent effects in animal studies including in mice, rats, and monkeys. However, it failed to produce psychedelic effects in humans at a dose of 25 mg, which was the highest dose tested due to 5-HT3 mediated side effects of nausea and gastrointestinal discomfort. However Alexander Shulgin claimed that a fully effective psychedelic dose could be reached by blocking 5-HT3 receptors using a 5-HT3 antagonist.




Chemistry


Quipazine is synthesized by reacting 2-chloroquinoline with piperazine.




See also


2C-B-PP
6-Nitroquipazine
Naphthylpiperazine
ORG-37684
Substituted piperazine




References

Kata Kunci Pencarian:

• Reseptor serotonin
• Quipazine
• 6-Nitroquipazine
• Substituted piperazine
• MDMA
• Ketamine
• List of drugs: Q
• LSD
• Cocaine
• Methylphenidate
• Sildenafil