• Source: Ralph S. Baric

Ralph Steven Baric (born 1954) is William R. Kenan Jr. Distinguished Professor in the Department of Epidemiology, and professor in the Department of Microbiology and Immunology at The University of North Carolina at Chapel Hill.
Baric's work involves coronaviruses, including gain of function research aimed at devising effective vaccines against coronaviruses. Baric has warned of emerging coronaviruses presenting as a significant threat to global health, due to zoonosis. Baric's work has drawn criticism from some scientists and members of the public related to chimeric virus experiments conducted at UNC-Chapel Hill.




Career


Baric has published multiple articles and book chapters on the epidemiology and genetics of various viruses, including norovirus, and coronaviruses, as well as potential treatments for viral diseases.
In 2015, with Shi Zhengli of the Wuhan Institute of Virology, he published an article titled "A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence," which describes their work in generating and characterizing a chimeric virus which added the spike of a bat coronavirus (SHC014) onto the backbone of a mouse-adapted SARS-CoV (rMA15). The research related to this article drew criticism from other scientists due to fears that the SHC014-rMA15 chimeric virus could have pandemic potential. This concern was renewed and echoed by members of the public during the COVID-19 pandemic. Experts have noted that the virus was adapted to a mouse model and had decreased virulence in human tissues. The chimeric virus was also less virulent than the wild type rMA15 virus, as is expected in most chimeras.
In 2020, Baric contributed to establishing the official nomenclature and taxonomic classification of SARS-CoV-2. In 2021, he was elected member of the U. S. National Academy of Sciences.




Selected publications


Vineet D Menachery; Boyd L Yount; Kari Debbink; et al. (9 November 2015). "A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence". Nature Medicine. 21 (12): 1508–1513. doi:10.1038/NM.3985. ISSN 1078-8956. PMC 4797993. PMID 26552008. S2CID 5953778. Wikidata Q36702376. (erratum)
Coronaviridae Study Group of the International Committee on Taxonomy of Viruses; Susan C. Baker; Christian Drosten; et al. (2 March 2020). "The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2". Nature Microbiology. 5 (4): 536–544. doi:10.1038/S41564-020-0695-Z. ISSN 2058-5276. PMC 7095448. PMID 32123347. S2CID 211729429. Wikidata Q87000965.
Evan J. Anderson; Nadine G Rouphael; Alicia T Widge; et al. (29 September 2020). "Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults". The New England Journal of Medicine. doi:10.1056/NEJMOA2028436. ISSN 0028-4793. PMC 7556339. PMID 32991794. Wikidata Q100381659.{{cite journal}}: CS1 maint: numeric names: authors list (link)




References






External links



Ralph S. Baric, PhD

Kata Kunci Pencarian:

• Ralph S. Baric
• Barić
• Lisa Hensley (microbiologist)
• North Carolina Award
• COVID-19 lab leak theory
• Zoonotic origins of COVID-19
• Shi Zhengli
• List of members of the National Academy of Sciences (Microbial biology)
• Samira Mubareka
• Murine coronavirus