• Source: RANBP1

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RANGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.




Interactions


RANBP1 has been shown to interact with XPO1, KPNB1 and Ran.




References






Further reading

Kata Kunci Pencarian:

• RANBP1
• WH1 domain
• List of human protein-coding genes 3
• Ran (protein)
• KPNB1
• XPO1
• Nuclear pore glycoprotein p62
• Stress granule
• RANBP2
• CCDC188