- Source: Ras superfamily
The Ras superfamily, derived from "Rat sarcoma virus", is a protein superfamily of small GTPases. Members of the superfamily are divided into families and subfamilies based on their structure, sequence and function. The five main families are Ras, Rho, Ran, Rab and Arf GTPases. The Ras family itself is further divided into 6 subfamilies: Ras, Ral, Rap, Rheb, Rad and Rit. Miro is a recent contributor to the superfamily. Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity.
The surrounding sequence helps determine the functional specificity of the small GTPase, for example the 'Insert Loop', common to the Rho subfamily, specifically contributes to binding to effector proteins such as WASP.
In general, the Ras family is responsible for cell proliferation: Rho for cell morphology, Ran for nuclear transport, and Rab and Arf for vesicle transport.
Subfamilies and members
The following is a list of human proteins belonging to the Ras superfamily:
Unclassified:
ARHGAP5
DNAJC27
GRLF1
RASEF
See also
Ras subfamily
References
Kata Kunci Pencarian:
- Burung pengicau
- Bakteriorodopsin
- Reseptor terhubung protein G
- Kecici daun pallas
- Ras superfamily
- Small GTPase
- Ras
- Ras GTPase
- RHEB
- GTPase
- HRAS
- Transforming protein RhoA
- Guanine nucleotide exchange factor
- RIT (disambiguation)
Litsoneras (2023)
Kamali from Nadukkaveri (2021)
Wonder Woman (2009)
Ponyo (2008)
Deranged (2012)
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