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    • Source: Rev-Erb

      • The Rev-Erb proteins are members of the nuclear receptor (NR) superfamily of intracellular transcription factors and key regulatory components of the circadian clock. There are two forms of the receptor, Rev-Erb alpha and Rev-Erb beta, which are each encoded by a separate gene (NR1D1 and NR1D2, respectively).
      These proteins act as key regulators of clock gene expression through transcriptional repression of Bmal1. Through their regulation of clock-controlled genes, the Rev-Erb proteins affect several physiological processes throughout the body, including metabolic, endocrine, and immune pathways.
      In the NRNC classification scheme, Rev-Erb is nuclear receptor subfamily 1 group D (NR1D). The name "Rev-Erb" derived by truncation from "Rev-ERBA" (Rev-ErbĪ±), which in turn was named because it was on the opposite strand of ERBA (THRA) oncogene. The paralogous Rev-ErbĪ² does not seem to have anything special on its reverse strand. Older sources may use "Rev-ERBA" as the family name.
      The receptors are potential drug targets for non-alcoholic steatohepatitis.


      See also


      Rev-Erbɑ
      Rev-ErbĪ²
      Nuclear Receptors
      Transcription Factors
      Circadian Clock


      References




      External links


      HZF-2alpha at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
      HZF-2beta at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
      NR1D1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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