- Source: Rheumatoid neutrophilic dermatitis
Rheumatoid neutrophilic dermatitis, also known as rheumatoid neutrophilic dermatosis, is a cutaneous condition associated with rheumatoid arthritis.
Signs and symptoms
Rheumatoid neutrophilic dermatitis occurs more frequently in patients with severe, persistent seropositive arthritis; it presents clinically as erythematous papules, nodules, plaques, or lesions resembling urticaria without any accompanying symptoms. Less common conditions include annular lesions, blisters, ulcers, and vesicles. Skin lesions are typically symmetrical, but they can occasionally be distributed asymmetrically. Dorsal surfaces of hands and arms are preferred sites, with an emphasis on the extensor surfaces of extremities and joints.
Diagnosis
Histopathological findings include normal epidermis, that may show hyperkeratosis, parakeratosis, focal ulceration with scaly crust, or spongiosis with intraepidermal blistering,
Treatment
Treatments include topical steroids, cyclophosphamide, dapsone, and hydroxychloroquine.
Outlook
Lesion resolution can happen on its own or as the rheumatoid arthritis progresses, but lesions usually recur when the condition gets worse. Although most lesions heal without leaving scars, hyperpigmentation may linger for a while.
See also
Sweet's syndrome-like dermatosis
List of cutaneous conditions
References
Further reading
Żuk, Gabriela; Jaworecka, Kamila; Samotij, Dominik; Ostańska, Elżbieta; Reich, Adam (December 31, 2019). "Rheumatoid neutrophilic dermatitis". Rheumatology. 57 (6). Termedia Sp. z.o.o.: 350–353. doi:10.5114/reum.2019.90363. ISSN 0034-6233. PMC 7091481. PMID 32226170.
"Rheumatoid neutrophilic dermatosis: A case report and literature review of current treatment options". Journal of the American Academy of Dermatology. 60 (3). Elsevier BV: AB52. 2009. doi:10.1016/j.jaad.2008.11.243. ISSN 0190-9622.