- Source: RivX sRNA
RivX sRNA is a non-coding RNA molecule involved in the interface between two key regulators of virulence in the human pathogen Streptococcus pyogenes (Group A Streptoccus, also known as GAS): the CovR/S system and Mga regulator. This RNA, along with its downstream protein-coding gene RivR, are the first discovered links between these two important regulation networks. An extra protein linking the two pathways, TrxR, was described a year later. The adjoining of these two pathways could allow a consistently high virulence of S. pyogenes despite a variety of environmental conditions.
RivX is thought to be co-transcribed with RivR mRNA before post-transcriptional processing releases the sRNA. It was found to be a non-coding transcript through site-directed mutagenesis experimentation.
In total, the GAS genome is now predicted to encode 75 total sRNAs, a number approximately equal to the number of transcription factors encoded by the genome, which shows the importance of RNA regulation in GAS.
References
External links
Page for RivX sRNA at Rfam