- Source: Ryanodine
Ryanodine is a poisonous diterpenoid found in the South American plant Ryania speciosa (Salicaceae). It was originally used as an insecticide.
The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it.
At nanomolar concentrations, ryanodine locks the receptor in a half-open state, whereas it fully closes them at micromolar concentration. The effect of the nanomolar-level binding is that ryanodine causes release of calcium from calcium stores as the sarcoplasmic reticulum in the cytoplasm, leading to massive muscle contractions. The effect of micromolar-level binding is paralysis. This is true for both mammals and insects.
See also
Diamide insecticides, a class of insecticides with the same mechanism of action as ryanodine
Ryanodine receptor
Dihydropyridine channel
References
Further reading
Santulli, Gaetano; Marks, Andrew (2015). "Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging". Current Molecular Pharmacology. 8 (2): 206–222. doi:10.2174/1874467208666150507105105. PMID 25966694.
Bertil Hille, Ionic Channels of Excitable Membranes, 2nd edition, Sinauer Associates, Sunderland, MA, 01375, ISBN 0-87893-323-9
Kata Kunci Pencarian:
- Reseptor (biokimia)
- Ryanodine
- Ryanodine receptor
- Ryanodine receptor 1
- Catecholaminergic polymorphic ventricular tachycardia
- Ryanodine receptor 2
- Sarcoplasmic reticulum
- Malignant hyperthermia
- Ryanodine receptor 3
- Chlorantraniliprole
- Dantrolene
