- Source: S53
S53 may refer to:
S53 (New York City bus), serving Staten Island
Dhurga language, an Australian Aboriginal language
S53: Avoid exposure - obtain special instructions before use, a safety phrase
Shorland S53, a British armoured car
Sikorsky S-53, an American helicopter
Tsonga language, a Bantu language
Saviem S53, a Saviem bus model
Toyota S53, a Toyota S transmission
ZIS-S-53, an Anti air and Anti-tank gun