• Source: Selenoprotein O

Selenoprotein O is a protein that in humans is encoded by the SELENOO gene.




Function


This gene encodes a selenoprotein, pseudokinase selenoprotein-O(SelO), that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The SELO protein AMPylates proteins involved in redox homeostasis. As a result this selenoprotein is thought to be necessary for the cellular response to oxidative stress.




References






Further reading



This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Kata Kunci Pencarian:

• Kodon stop
• Selenium
• Selenoprotein O
• Selenoprotein
• SECIS element
• SELT
• Selenium deficiency
• Selenocysteine
• SEPW1
• List of biomolecules
• SEPP1
• Selenium