• Source: SMG1

Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene. SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.




Function


This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.




Interactions


SMG1 (gene) has been shown to interact with PRKCI and UPF1.




References






Further reading

Kata Kunci Pencarian:

• SMG1
• Exon junction complex
• Nonsense-mediated decay
• Stress granule
• List of human protein-coding genes 4
• MRNA surveillance
• SMG6
• UPF1
• Phosphatidylinositol 3-kinase-related kinase
• Telomeric repeat–containing RNA