• Source: SnRNP70

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.




Interactions


snRNP70 has been shown to interact with ASF/SF2, SRPK1, and ZRANB2.




Role in autoimmunity


Antibodies towards snRNP70 are associated with mixed connective tissue disease.




References






Further reading

Kata Kunci Pencarian:

• SnRNP70
• Anti-nRNP
• List of human protein-coding genes 4
• Serine/arginine-rich splicing factor 1
• Corinne Houart